A randomized study, published in the Journal of Cosmetic Dermatology (online April 25, 2019) found that chemicals peels are significantly more effective at reducing periorbital hyperpigmenation than injection of platelet-rich plasma. Researchers Noha Kamel, MD, et al, treated 42 patients, who were randomly assigned to one of two groups. Group A received four sessions of chemical peeling using trichloroacetic acid and lactic acid, while group B underwent four sessions of PRP injection at two week intervals. Digital photographs were used to assess outcomes based on a four-degree scale (poor to excellent).
In group A (chemical peeling), 38 percent of patients had excellent results and 47.6 percent had good results. In group B, 4.8 percent had good results and zero patients had excellent improvement. There was no significant difference in the rate of adverse events. Group A patients experienced itching (14.3 percent) and redness (14.3 percent). Group B patients experienced pain (23.8 percent) and edema (14.3 percent).
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