Building on earlier research conducted by R. Rox Anderson, MD, that identified 1720nm as a wavelength capable of selectively targeting sebum, William Lewis, MD, presented a study using two prototype diode lasers—1700nm and 1720nm—to create selective photothermolysis of the sebaceous glands. The researchers irradiated porcine ear secretions using no cooling, and then stained them with nitro blue tetrazolium chloride staining (NBTC) to detect thermal denaturation. Preliminary findings showed greater selectivity for sebum at 1720nm versus 1700nm—Dr. Lewis postulated that a 1726nm laser might be optimal—and a threshold for consistent thermal denaturation at approximately 40 J/cm2. The researchers called for further studies to define optimal parameters, including pulse duration, fluence and skin cooling.
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